Feelings of hopelessness,guilt, helplessness, worthlessness
Loss of interest in hobbies and activities that were once enjoyed, including sex
Loss of energy
Difficulty concentrating, remembering, making decisions
Lack sleep, early-morning awakening, or oversleeping
Weight gain or weight loss
Thoughts of death or suicide; suicide attempts
Restlessness,
Irritability
Persistent physical symptoms that do not respond to treatment, such as headaches, digestive disorders, and chronic pain
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